abstract：INTRODUCTION:Development of efficient in vivo delivery systems remains a major challenge en route to clinical application of antisense technology, including RNA-cleaving molecules such as deoxyribozymes (DNAzymes). The mechanisms of oligonucleotide uptake and trafficking are clearly dependent on cell type and the type ...

journal_title：Expert opinion on drug delivery

authors： Fokina AA,Chelobanov BP,Fujii M,Stetsenko DA

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:Cancer initiating or stem cells (CSCs) are a small population of cells in the tumor mass, which have been reported to be present in different types of cancers. CSCs usually reside within the tumor and are responsible for reoccurrence of cancer. The imprecise, inaccessible nature and increased efflux of con...

journal_title：Expert opinion on drug delivery

authors： Ahmad G,Amiji MM

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:Nanomedicine has emerged as a major field of academic research with direct impact on human health. While a first generation of products has been successfully commercialized and has significantly contributed to enhance patient's life, recent advances in material design and the emergence of new therapeutics ...

journal_title：Expert opinion on drug delivery

authors： Ragelle H,Danhier F,Préat V,Langer R,Anderson DG

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Injectable life-saving drugs should not be exposed to temperatures <4°C/39°F or >30°C/86°F. Frequently, weather conditions exceed these temperature thresholds in many countries. Insulin is to be kept at 4-8°C/~ 39-47°F until use and once opened, is supposed to be stable for up to 31 days at room temperature ...

journal_title：Expert opinion on drug delivery

authors： Pfützner A,Pesach G,Nagar R

更新日期：2017-06-01 00:00:00

abstract：INTRODUCTION:Neurodegenerative diseases (NDs) represent a group of different clinical entities that, despite the specific primary etiologies, share a common signature in terms of a general mitochondrial dysfunction with consequent oxidative stress accumulation. As these two events occur early during neurodegenerative p...

journal_title：Expert opinion on drug delivery

authors： Pezzini I,Mattoli V,Ciofani G

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The present work focuses on the development of ultra-small solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) encapsulating cyclosporine and calcipotriol, further incorporated into gel, increasing their penetration through the skin. RESEARCH DESIGN AND METHODS:Developed SLN and NLC were...

journal_title：Expert opinion on drug delivery

authors： Arora R,Katiyar SS,Kushwah V,Jain S

更新日期：2017-02-01 00:00:00

abstract：INTRODUCTION:Cancer is a leading cause of death worldwide and efficient new strategies are urgently needed to combat its high mortality and morbidity statistics. Fortunately, over the years, nanotechnology has evolved as a frontrunner in the areas of imaging, diagnostics and therapy, giving the possibility of monitorin...

journal_title：Expert opinion on drug delivery

authors： Luque-Michel E,Imbuluzqueta E,Sebastián V,Blanco-Prieto MJ

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Augmentation of simvastatin (SMV) cytotoxicity in breast carcinoma cell lines MCF-7, by: improvement of cellular uptake and loading on alpha lipoic acid (ALA). METHODS:In this study, SMV was loaded on ALA nanoparticles and characterized for surface morphology, SMV entrapment efficiency percent (%EE), zeta p...

journal_title：Expert opinion on drug delivery

authors： Fahmy UA,Aljaeid BM

更新日期：2016-12-01 00:00:00

abstract：INTRODUCTION:Glioblastoma is a type of brain cancer arises from glial cells. Glioblastoma multiforme (GBM), a subtype of glioblastoma, is the most common and most aggressive primary brain tumor. Currently, GBM therapy includes surgery and post-operative high-doses of radiation and chemotherapy. This therapeutic strateg...

journal_title：Expert opinion on drug delivery

authors： Gutkin A,Cohen ZR,Peer D

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:Diabetic Retinopathy (DR) is one of the most common causes of blindness among the working population worldwide. Clearly, there is an unmet clinical need to find better treatment options for DR. Areas covered: The literature search was conducted on PubMed with no limitation on language or year of publicatio...

journal_title：Expert opinion on drug delivery

authors： Nirmal J,Radhakrishnan K,Moreno M,Natarajan JV,Laude A,Lim TH,Venkatraman S,Agrawal R

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:Simvastatin (SV) is a drug from the statin class, currently used orally as an anti-cholesterolemic drug. It inhibits the 3-hydroxy-3-methyl-glutaryl-Coenzyme A (HMG-CoA) reductase to reduce cholesterol synthesis. Recently, it has been found that SV also has several other protective pharmacological actions ...

journal_title：Expert opinion on drug delivery

authors： Tulbah AS,Ong HX,Colombo P,Young PM,Traini D

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Viral and non-viral vectors have been used as methods of delivery in gene therapy for many CNS diseases. Currently, viral vectors such as adeno-associated viruses (AAV), retroviruses, lentiviruses, adenoviruses and herpes simplex viruses (HHV) are being used as successful vectors in gene therapy at clinica...

journal_title：Expert opinion on drug delivery

authors： Jayant RD,Sosa D,Kaushik A,Atluri V,Vashist A,Tomitaka A,Nair M

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:To develop orodispersible films (ODF) based on hydrophobic polymers with higher stability to ordinary environmental humidity conditions without compromising their fast disintegration time. METHODS:A quality by design approach was applied to screen three different formulations each one based on a different h...

journal_title：Expert opinion on drug delivery

authors： Borges AF,Silva BM,Silva C,Coelho JF,Simões S

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Polymers can be designed to modify their features as a function of the level and nature of the surrounding microorganisms. Such responsive polymers can endow drug delivery systems and drug-medical device combination products with improved performance against intracellular infections and biofilms. AREAS CO...

journal_title：Expert opinion on drug delivery

authors： Alvarez-Lorenzo C,Garcia-Gonzalez CA,Bucio E,Concheiro A

更新日期：2016-08-01 00:00:00

abstract：INTRODUCTION:Topical drug delivery is a challenging area with many advantages such as avoidance of first passage effect, stabilization of blood concentrations and attainment of local therapeutic effect with fewer side effects. Despite all these advantages, topical drug delivery remains limited to few molecules, since s...

journal_title：Expert opinion on drug delivery

authors： Marto J,Ascenso A,Simoes S,Almeida AJ,Ribeiro HM

更新日期：2016-08-01 00:00:00

abstract：INTRODUCTION:Liposomes are well-known as drug carriers, and are now critical components of two of six types of adjuvants present in licensed vaccines. The liposomal vaccine adjuvant field has long been dynamic and innovative, and research in this area is further examined as new commercial products appear in parallel wi...

journal_title：Expert opinion on drug delivery

authors： Alving CR,Beck Z,Matyas GR,Rao M

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:Nanocomposite microparticles are intelligent carriers utilised for pulmonary drug delivery. These carriers are composed of drug-encapsulated nanoparticles dispersed in microstructures of polysaccharides. Upon administration, the inhaled microparticles can penetrate and be deposited deeply in the lung due t...

journal_title：Expert opinion on drug delivery

authors： Elsayed I,AbouGhaly MH

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:This study focuses on the development of amlodipine bilayer buccal tablets of hydroxypropyl methylcellulose (HPMC) matrix system containing polyacrylate polymer (Carbopol(®))/β-cyclodextrin as the drug layer and ethylcellulose as the non-swellable backing layer, and their biointerfacial phenomena. METHODS:T...

journal_title：Expert opinion on drug delivery

authors： Panda B,Subhadarsini R,Mallick S

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Oral delivery of therapeutic peptide hormones offers the promise of greater patient compliance when compared to parenteral administration routes. However, it is a huge challenge in the pharmaceutical field. Due to increasing demand for oral delivery of peptide hormones such as insulin, gonadotropin-releasi...

journal_title：Expert opinion on drug delivery

authors： Varamini P,Toth I

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Inflammatory bowel disease (IBD) is a chronic autoimmune disease, whose main forms are Crohn's disease and ulcerative colitis. The main treatment of IBD includes oral administration of anti-inflammatory or immunosuppressive agents enclosed in traditional dosage forms, intended to release the active ingredi...

journal_title：Expert opinion on drug delivery

authors： Youshia J,Lamprecht A

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Utilizing the prodrug approach as a method to overcome various pharmaceutical and pharmacokinetic barriers to drug delivery is significantly accelerating and achieving successes. In contrast to the older traditional prodrugs which suffer from decreased bioavailability and a high profile of side effects, du...

journal_title：Expert opinion on drug delivery

authors： Amly W,Karaman R

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Overactive bladder affects a significant portion of the population and results in prescribing of numerous medications for its treatment. Traditional drug delivery systems used in therapy are associated with multiple commonly reported side effects. Adherence rates with use of these medications are low. It i...

journal_title：Expert opinion on drug delivery

authors： Scott K,Dmochowski RR,Padmanabhan P

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Topically applied small interfering RNA (siRNA) can be an effective treatment for skin disorders. Using noninvasive strategies can be a safe and effective siRNA-permeation-enhancement approach for facilitating skin delivery. It has been demonstrated that noninvasive approaches for enhancing siRNA transport...

journal_title：Expert opinion on drug delivery

authors： Aljuffali IA,Lin YK,Fang JY

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Delivery of macromolecular drugs is an important field in medical research. However, macromolecules are usually unable to cross the cell membrane without the assistance of a delivery system. Cell penetrating peptides (CPPs) are unique tools to gain access to the cell interior and deliver a bioactive cargo ...

journal_title：Expert opinion on drug delivery

authors： Kurrikoff K,Gestin M,Langel Ü

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to improve the drug loading (DL) and stability of clarithromycin (CLA)-loaded liposomes, and reduce the irritation caused by intravenous administration of CLA. METHODS:A CLA-cholesteryl hemisuccinate (CHEMS) ion pair (CIP) was prepared by the solvent evaporation method and confirmed...

journal_title：Expert opinion on drug delivery

authors： Geng S,Liu X,Xu H,Cai C,Zhang Y,Yao Q,Xu H,Gou J,Yin T,Xiao W,Tang X

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:The aim of this work is to synthesize a novel stable and biodegradable nitric oxide (NO) donor polymer based on a chitosan backbone. This polymer needed to be linked to glutathione (GSH), which was nitrosated in a second step. This polymer has been developed as an NO delivery platform that could be further e...

journal_title：Expert opinion on drug delivery

authors： Shah SU,Martinho N,Socha M,Pinto Reis C,Gibaud S

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:The aim of the present study is to evaluate the influence of factors such as biopharmaceutical properties and study protocol on the emptying of pellets from the human stomach in a fed state. METHODS:A systematic literature search for data on human gastric emptying of pellets from a fed stomach state investi...

journal_title：Expert opinion on drug delivery

authors： Bürmen B,Locatelli I,Mrhar A,Bogataj M

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:Methotrexate (MTX) is a chemotherapeutic and anti-inflammatory drug that may cause systemic adverse effects. This study investigated kinetics and biodistribution of MTX delivered topically by ablative fractional laser (AFXL). METHODS:In vitro passive diffusion of 10 mg/ml MTX (1 w/v%) was measured from 0.25...

journal_title：Expert opinion on drug delivery

authors： Taudorf EH,Lerche CM,Vissing AC,Philipsen PA,Hannibal J,D'Alvise J,Hansen SH,Janfelt C,Paasch U,Anderson RR,Haedersdal M

更新日期：2015-07-01 00:00:00

abstract：INTRODUCTION:Apart from statins, anti-platelet agents and invasive procedures, the anti-atherosclerotic medical weaponry for coronary heart disease (CHD) is scarce and only partially protects CHD patients from major adverse cardiac events. AREAS COVERED:Several novel non-invasive strategies are being developed to wide...

journal_title：Expert opinion on drug delivery

authors： Maranhão RC,Tavares ER

更新日期：2015-07-01 00:00:00

abstract：INTRODUCTION:Respiratory infections and diseases are accompanied by or exhibit inflammation. Recent advances in nanoparticle engineering technology, together with the increased knowledge of inflammatory pathophysiology, have ignited interest in the pulmonary delivery of anti-inflammatory agents (AIAs) to achieve local ...

journal_title：Expert opinion on drug delivery

authors： Ali ME,McConville JT,Lamprecht A

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:Pressurized metered dose inhalers (pMDIs) are evolving to be a very effective drug delivery option in patients with airway diseases. They offer comparable lung deposition and reduced oropharyngeal deposition similar with the dry powder inhalers. As recommended by the Global Initiative for Asthma guidelines...

journal_title：Expert opinion on drug delivery

authors： Mehta N,Aggarwal B,Gogtay J,Abdool-Gaffar S

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:Rapid clearance of drugs from the body results in short therapeutic half-life and is an integral property of many protein and peptide-based drugs. To maintain the desired therapeutic effect patients are required to administer higher doses more frequently, which is inconvenient and risks undesirable side ef...

journal_title：Expert opinion on drug delivery

authors： Sleep D

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:The ever-increasing developments in pharmaceutical formulations have led to the widespread use of biodegradable polymers in various forms and configurations. In particular, interpenetrating network (IPN) and semi-IPN polymer structures that are capable of releasing drugs in a controlled manner have gained ...

journal_title：Expert opinion on drug delivery

authors： Aminabhavi TM,Nadagouda MN,More UA,Joshi SD,Kulkarni VH,Noolvi MN,Kulkarni PV

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:The work presents the development of acellular scaffolds extemporaneously embedded with platelet lysate (PL), as an innovative approach in the field of tissue regeneration/reparation. PL embedded scaffolds should have a tridimensional architecture to support cell migration and growth, in order to restore s...

journal_title：Expert opinion on drug delivery

authors： Sandri G,Bonferoni MC,Rossi S,Ferrari F,Mori M,Cervio M,Riva F,Liakos I,Athanassiou A,Saporito F,Marini L,Caramella C

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Diseases of the inner ear include those of the auditory and vestibular systems, and frequently result in disabling hearing loss or vertigo. Despite a rapidly expanding pipeline of potential cochlear therapeutics, the inner ear remains a challenging organ for targeted drug delivery, and new technologies are...

journal_title：Expert opinion on drug delivery

authors： Ayoob AM,Borenstein JT

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Amphiphilic block copolymers are recognized components of parenteral drug nanocarriers. However, their performance in oral administration has barely been evaluated to any great extent. AREAS COVERED:This review provides an overview of the methods used to prepare drug-loaded polymeric micelles and to evalu...

journal_title：Expert opinion on drug delivery

authors： Simões SM,Figueiras AR,Veiga F,Concheiro A,Alvarez-Lorenzo C

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Even though pulmonary diseases are among the leading causes of morbidity and mortality in the world, exceedingly few life-prolonging therapies have been developed for these maladies. Relief may finally come from nanomedicine and targeted drug delivery. AREAS COVERED:Here, we focus on four conditions for w...

journal_title：Expert opinion on drug delivery

authors： Brenner JS,Greineder C,Shuvaev V,Muzykantov V

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:In the therapy of clinical diseases such as cancer, it is important to deliver drugs directly to tumor sites in order to maximize local drug concentration and reduce side effects. This objective may be realized by using 'smart' nanoparticles (NPs) as drug delivery systems, because they enable dramatic conf...

journal_title：Expert opinion on drug delivery

authors： Fang Z,Wan LY,Chu LY,Zhang YQ,Wu JF

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:Thermosensitive chitosan/glycerophosphate (C/GP) solutions exhibiting sol-gel transition around body temperature were prepared to develop a class of injectable hydrogel platforms for the imaging and loco-regional treatment of hepatocellular carcinoma (HCC). Indocyanine green (ICG) was loaded in the thermosen...

journal_title：Expert opinion on drug delivery

authors： Salis A,Rassu G,Budai-Szűcs M,Benzoni I,Csányi E,Berkó S,Maestri M,Dionigi P,Porcu EP,Gavini E,Giunchedi P

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Macromolecular therapeutics, including enzymes, transcription factors, siRNAs, peptides and large synthetic molecules, can potentially be used to treat human diseases by targeting intracellular molecular pathways and modulating biological responses. However, large macromolecules have no ability to enter ce...

journal_title：Expert opinion on drug delivery

authors： Lönn P,Dowdy SF

更新日期：2015-01-01 00:00:00